Well, one of the world's distinguished leaders in myeloma, Gareth Morgan is at it again, bringing us significant clinical news on the presentation and progression of myeloma. As was previously mentioned in the HR-MM series, the cytogenetic changes of the myeloma cell form the basis for clonal evolution and are driving to plasma cell leukemia(PCL). The mutations enable the cell to dominate and win the protein wars. Morgan along with Walker f
Alright, I have selected another difficult topic to post about. While attempting to write about and explain immune checkpoints I decided that music and orchestras make a good metaphor for the immune system. Beautiful music relies on the pitch & sound of different instruments to be coordinated and our immune system also relies on checkpoint molecules (instruments) knowing when it is their turn to play (the right notes) and for how lo
The 18th Congress of the European Hematology Association (EHA) has convened this weekend in Stockholm, Sweden. The EHA membership includes over 100 countries and myeloma experts from across the globe have submitted abstracts of clinical significance for discussion and presentation. Many of the abstracts were presented at ASCO which just ended. There are a few that I believe are worth hig
“The current definition of multiple myeloma that requires end-organ damage is outdated. We are now saying there are other factors besides end organ damage that can be used to identify patients who need therapy.”
Earlier Intervention is Key
In a News& Views write up from Nature Reviews, Dr. Rajkumar, G. Merlini,& J.F. SanMiguel discuss redefining myeloma and in particular redefining treatment guidelines for SMM.
Ok, so the first post of the series covered Trisomies because when you talk about cytogenetics or HR-MM, you might as well call it the the good, the bad, and the ugly and I wanted to start out with the good. Yep, it's all downhill from here, so get your skis or head out for Insano.
Next up are translocations.
I am the sort of person who likes to see the big picture first before I get bogged down in the details, as it helps to understand the ove
This is a long post and the information is complex.
However, I can assure you it is well worth your time even if it may take awhile to digest (i.e. read multiple times). I can't tell you how many times I had to read & re-read science information to become 'educated' lol. I did it. You can too. My tip, just read a bit. Digest it. Then come back and read some more. It is well worth it as it matters to be an informed patient. Especial