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Dr. Ola Langren on: CD 38 MAB’...

https://www.youtube.com/watch?v=laPGOid7b5M&feature=youtu.be...

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RRMM: Carfilzomib/Panobinostat Effe...

In patients with relapsed/refractory multiple myeloma, the combination of panobinostat (Farydak) and carfilzomib (Kyprolis) appears to be safe and eff...

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Genomic Testing: AACC concerned abo...

NGS  aka Genomic testing can be  a boon  in our lives and/or raise expectations with potential societal discrimination.  The concern from ACCC about o...

RRMM

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RRMM: Carfilzomib/Panobinostat Effective

In patients with relapsed/refractory multiple myeloma, the combination of panobinostat (Farydak) and carfilzomib (Kyprolis) appears to be sa...

Immunotherapy

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Dr. Ola Langren on: CD 38 MAB’s

https://www.youtube.com/watch?v=laPGOid7b5M&feature=youtu.be...

HAPPY EASTER!

th... [Read More]

Dr. Ola Langren on: CD 38 MAB’s

... [Read More]

RRMM: Carfilzomib/Panobinostat Effective

imagesIn patients with relapsed/refractory multiple myeloma, the combination of panobinostat (Farydak) and carfilzomib (Kyprolis) appears to be safe and effective, according to a phase I/II study by Berdeja et al in Haematologica. Further evaluation of this combination treatment is warranted to establish the optimal dose and schedule... [Read More]

Genomic Testing: AACC concerned about FDA overegulation

thNGS  aka Genomic testing can be  a boon  in our lives and/or raise expectations with potential societal discrimination.  The concern from ACCC about overregulation is valid in terms of accessibility and possibly warranted. You decide. The issue is real. Let your voice be heard.  Get involved.... [Read More]

# EBMT15: ISTANBUL Tweets of interest to MM pts

EBMT logoVisit Twitter today for the most recent news coming out of #EuropeanBone MarrowTransplant15…lots of good tweets!  Here are a few twitter highlights.... [Read More]

SECOND CANCER

Got the call.  Staring down the throat of ANOTHER one!!  The MOB is a bad MOFO. Gotta kill Barzini!  I knew to kill that SOB,didn’t get ‘em & now that SOB  is BACK elsewhere!!   His days are numbered. Believe that. They can excise this MOFO..just gotta pray no lymph node involvement. My Gmom had it..but I don’t need it. CUT IT OUT!!  Get it before it spreads!... [Read More]

Is there HYPE about GENOMIC testing? YOU bet!

You decide.. always helpful to hear more  than one POV.. I tried to get the data to post 2 my site.... [Read More]

Genetic Testing of Your Myeloma May Change Your Life

... [Read More]

Cancer Hallmarks: Drugs Targeting Signaling Pathways for MM

Cancer functional pathways-lgSignaling pathways  are one hallmark of  how the cancer regulates and/or changes our normal  cell functions to  control  signals and  sustain growth & survival of the tumor.
This post identifies what those signaling pathways are  specific to  myeloma along with the agents presently available to target the pathway.
A lot of research has been done in this area when it comes to MM signaling pathways and there are almost 10  pathways which have been identified:   HDAC, PI3K/AKT/mTOR, p38 MAPK, Hsp90, Wnt, Notch, Hedgehog, and cell cycle.... [Read More]

TEN Hallmarks of Cancer

[caption id="attachment_4708" align="aligncenter" width="300"]Michael Corleone godfather28 “Lose a father or gain a husband” Michael Corleone[/caption]

My name is Michael Corleone. There are people who’d pay a lot of money for that information. But then your daughter would lose a father instead of of gaining a husband.”... [Read More]

PIM Kinases and their Role in Myeloma

[caption id="attachment_1019" align="alignleft" width="172"]Robert Orlowski, M.D. MD Anderson Cancer Robert Orlowski, M.D.
MD Anderson Cancer[/caption]

There are certain voices in the myeloma community that are like EF Hutton to me.  Typically, the voice speaking turns out to be one of the  myeloma experts like Ravi, Richardson, Anderson, Landgren or Orlowski. ( yep, the M.D. PhD. guys) This happened to me today as I was listening to an interview with Dr. Orlowski at Crowd Care.  I heard the words Pim Kinase and was like, hmmm, what’s that?   Well, turns out this group of kinases are one of the new targeted therapies for myeloma.... [Read More]

CAR’s @ ASH 2014 Targeted Therapy IV: ELOTUZUMAB

[caption id="attachment_4594" align="alignleft" width="238"]NK CD56 dim or bright NK cells with SLAM receptors[/caption]

 ... [Read More]

CAR’s @ASH 2014 Targeted Therapy III: CS-1

Next up CS-1 MAB aka elotumumab aka HuLuc63. Yes, that Hu is for humanized..  MAB’s, as we know, are categorized by the biomarker on the T-cell they target. Why has Elotuzumab changed from a  CS-1  to a SLAMF7 MAB targeted therapy.? What is SLAM?  Why is it numbered?  What does that mean in terms of efficacy?. Why do lo-doses work better and what is it’s safety profile?. How does it work?... [Read More]

CAR’s @ASH 2014 Targeted Therapy II: BCMA

ONC1006p1375f1
Ok, we have a baseline now lets add some to it.... [Read More]

Check Point Inhibitors & MAB’s @ ASH 2014 Targeted Therapy

imagesDid you hear about those great Checkpoint Inhibitors at ASH 2014?  OMG they are gangbusters!!  They work across MANY cancers (lung, melanoma, Hodgkins).  We are going to have them soon to treat myeloma.  What do you know about them?  How do they work? What is the response rate?    How do they compare?... [Read More]